[Causes of sudden death during sports activities in Spain]. Hong Kong Med J. While knowing the cause of SCD is one of the favorites of the physicians involved with these cases, it is very difficult and challenging task for the forensic physician. Risk stratification for sudden cardiac death a plan for the future. A study of mortality risk factors among trauma referrals to trauma center, Shiraz, Iran, 2017. N Engl J Med. Distinctive profile of sudden cardiac arrest in middle-aged vs. older adults: a community-based study. Pathogenesis of sudden unexpected death in a clinical trial of patients with myocardial infarction and left ventricular dysfunction, heart failure, or both clinical perspective. Cardiogenetics, 25 years a growing subspecialism. Conclusions: Heart Rhythm. Cardiol Rev. The material was divided into natural and unnatural groups. Epub 2017 Jul 27. This includes the primary arrhythmogenic disorders such as long QT syndromes and inherited cardiomyopathies, namely hypertrophic cardiomyopathy. Findings in others included coronary artery anomalies (n = 3), myocarditis (n = 2), hypertrophic cardiomyopathy (n = 1), coronary artery dissection (n = 1) and accessory pathway (n = 1). Please enable it to take advantage of the complete set of features! 2010;122(6):597–602. 2006 Jul-Aug;14(4):161-3. doi: 10.1097/01.crd.0000197965.99826.b2. Prospective Countywide Surveillance and Autopsy Characterization of Sudden Cardiac Death: POST SCD Study. Forensic Sci Int. Circulation. Methods: We reviewed autopsy and detailed cardiac pathologic findings in younger women (age 35-44 years) from a 270-patient, 13-year (1984-1996) autopsy series of sudden cardiac death, and performed comparisons with findings in age-matched men. 2014 Oct 21;130(17):1474-82. doi: 10.1161/CIRCULATIONAHA.114.011489. Eckart RE, Jones SO 4th, Shry EA, Garrett PD, Scoville SL. While coronary artery disease and acute myocardial infarction are the most common causes of SCD in older populations, genetic (inherited) cardiac disorders comprise a substantial proportion of SCD cases aged 40 years and less. Barretta F, Mirra B, Monda E, Caiazza M, Lombardo B, Tinto N, Scudiero O, Frisso G, Mazzaccara C. Int J Mol Sci. 2014 Apr;7(2):205-11. doi: 10.1161/CIRCEP.113.001421. Coronary occlusion was the major contributory cause of sudden death with cardiac origin and the highest number of deaths were reported in the age 50-59 years with male to female ratio of 10:1. Incidence of sudden cardiac death in national collegiate athletic assoc-iation athletes. Results: 2016 Oct;32(5):359-365. doi: 10.1016/j.joa.2015.09.010. Where no cause of death is identified, genetic testing of deoxyribonucleic acid extracted from postmortem blood (the molecular autopsy) may identify a cause of death in up to 30% of SADS cases. USA.gov. Management of families following SCD begins with a concerted effort to identify the cause of death in the decedent, based on either premorbid clinical details or the pathological findings at postmortem. 2013 Oct 9;168(4):3495-9. doi: 10.1016/j.ijcard.2013.04.207. Epub 2014 Oct 13. Circ Res. Irrespective of the genetic testing considerations, all families in which a sudden unexplained death has occurred require targeted and standardized clinical testing in an attempt to identify relatives who may be at-risk of having the same inherited heart disease and therefore also predisposed to an increased risk of SCD. NLM The present report is a prospective study regarding cause of SCDs on autopsy examination in four-year period, Bangalore, India. Sudden cardiac death (SCD) is a devastating and tragic outcome of a number of underlying cardiovascular diseases. eCollection 2020. A presumptive cause of sudden cardiac death could not be determined in 13 women (50%). A total of 2449 autopsy was conducted of which 204 cases were due to SCD. Risgaard B, Winkel BG, Jabbari R, Behr ER, Ingemann-Hansen O, Thomsen JL, Ottesen GL, Gislason GH, Bundgaard H, Haunsø S, Holst AG, Tfelt-Hansen J. Circ Arrhythm Electrophysiol. 2018 Dec;18(4):942-949. doi: 10.4314/ahs.v18i4.13. The major cardiac pathology resulting in sudden death was coronary artery disease (n-116; 56.86%) and myocardial infarction (n-104; 50.9%). Grubic N, Puskas J, Phelan D, Fournier A, Martin LJ, Johri AM. Prevalence and pattern of cardiovascular-related causes of out-of- hospital deaths in Lagos, Nigeria. Epub 2013 Aug 22. The present prospective study is based on autopsy observations, carried out for four-year period from 2008 to 2011, and analyzed for cause of SCDs. Women aged 35 to 44 years constituted 32% of all women in the series compared to men, who constituted 24% of total men (P =.004 vs women). Haïssaguerre M, Duchateau J, Dubois R, Hocini M, Cheniti G, Sacher F, Lavergne T, Probst V, Surget E, Vigmond E, Welte N, Chauvel R, Derval N, Pambrun T, Jais P, Nademanee W, Bernus O. JACC Clin Electrophysiol. Gender differences in sudden cardiac death in the young-a nationwide study. Clipboard, Search History, and several other advanced features are temporarily unavailable. Arch Mal Coeur Vaiss. Due to under-representation of younger adults in published autopsy series, etiologies of sudden cardiac death merit further investigation. SVAD: A genetic database curates non-ischemic sudden cardiac death-associated variants. In 24 (11.8%) cases major narrowing was noted in both the main coronaries, in 87 (42.6%) cases in the left anterior descending coronary artery (LAD), and in 18 (51.5%) cases in the right coronary artery (RCA). | Given the dynamic and multifactorial nature of sudden cardiac death, comprehensive population-based investigations are likely to be necessary to further investigate this unexpected sex-based disparity. | Genetics; Molecular autopsy; Multidisciplinary care; Postmortem; Specialized clinic; Sudden cardiac death. Aim Sudden unexplained nocturnal death syndrome (SUNDS) has been linked to the Brugada syndrome. Sudden unexplained deaths (SUD) are those where no cause is found after detailed premorbid history and a complete autopsy with macroscopic, histological and toxicology assessment. 2017 Sep;13(3):336-341. doi: 10.1007/s12024-017-9888-z. The spectrum of epidemiology underlying sudden cardiac death. Optimal care of SCD families therefore requires dedicated and appropriately trained staff in the setting of a specialized multidisciplinary cardiac genetic clinic. Sudden cardiac death (SCD) is a devastating and tragic outcome of a number of underlying cardiovascular diseases. CAD: coronary artery disease; MI: myocardial infarction; VR: ventricular…, Percentage of blockage of coronary artery, NLM Faduyile FA, Soyemi SS, Sanni DA, Wright KO. CAD: coronary artery disease; MI: myocardial infarction; VR: ventricular rupture; RHD: rheumatic heart disease; HHD: hypertensive heart disease; HCM: hypertrophic cardiomyopathy; ACM: alcoholic cardiomyopathy; AH: aneurysm of heart; RCM: restrictive cardiomyopathy. Ding Z, Yang M, Wang Y, Wu S, Qiu X, Liu Q. Forensic Sci Med Pathol. Noheria A, Teodorescu C, Uy-Evanado A, Reinier K, Mariani R, Gunson K, Jui J, Chugh SS. Between 1989 and 1998 there was a 21% increase in estimated sudden cardiac death among US women aged 35 to 44 years. Methods: NIH The sudden death of a young, apparently fit and healthy person is amongst the most challenging scenarios in clinical medicine. Incidence of sudden cardiac death (SCD) has been steadily increasing all over the world. Epub 2014 Mar 6. Winkel BG, Risgaard B, Bjune T, Jabbari R, Lynge TH, Glinge C, Bundgaard H, Haunsø S, Tfelt-Hansen J. BMC Cardiovasc Disord. The maximum number of deaths (n=78) was within few hours (6 hours) after the onset of signs and symptoms. A cause of Sudden Cardiac Deaths on Autopsy Findings; a Four-Year Report. Methods: NLM 2017 Jan 7;17(1):19. doi: 10.1186/s12872-016-0446-5. Studies conducted in our country reveal that cardiovascular origined deaths are the Mak CM, Mok NS, Shum HC, Siu WK, Chong YK, Lee HHC, Fong NC, Tong SF, Lee KW, Ching CK, Chen SPL, Cheung WL, Tso CB, Poon WM, Lau CL, Lo YK, Tsui PT, Shum SF, Lee KC. One of the serious challenges that pathologists are facing is the significant decline of the overall autopsy rate. | HHS Circulation. This site needs JavaScript to work properly. Get the latest research from NIH: https://www.nih.gov/coronavirus. Key role of the molecular autopsy in sudden unexpected death. Curr Opin Cardiol. Sudden cardiac death is described as death that occur within the 1st hour of the onset of the symptoms or death within the 24 hours of the onset of symptoms in unwitnessesed deaths. In up to 30% of young SCD, no cause of death is identified at postmortem, so-called autopsy-negative or sudden arrhythmic death syndrome (SADS). N-terminal pro-B-type natriuretic peptide is associated with sudden cardiac death risk: the Cardiovascular Health Study. Get the latest research from NIH: https://www.nih.gov/coronavirus. HHS Conclusion: Methods and results A case control autopsy … Familial cardiological and targeted genetic evaluation: low yield in sudden unexplained death and high yield in unexplained cardiac arrest syndromes.
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