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The microbes were winning. “You can go into a hospital and you will have a four in a hundred chance of getting an infection you’ve never had before, while in that hospital.
We have been neglectful of the microbes, and that is a recurring theme that is coming back to haunt us.”, “While the human race battles itself, fighting over ever more crowded turf and scarcer resources, the advantage moves to the microbes’ court. It seemed perfectly reasonable therefore to assume that the evolution of microbes capable of infecting Homo sapiens would accelerate, perhaps dramatically.”, “Ultimately, humanity will have to change its perspective on its place in Earth’s ecology if the species hopes to stave off or survive the next plague. In the microbial world warfare is a constant. Laurie Garrett's book The Coming Plague: Newly Emerging Diseases in a World Out of Balance is nearly 20 years old but it offers very interesting background information about the first round of Ebola in Africa, plus important discussion of how diseases develop and spread. Our Privacy Notice has been updated to explain how we use cookies, which you accept by continuing to use this website. —Richard Preston, New York Times-bestselling author of The Hot Zone.
Efforts to eradicate malaria severely disrupted that balance. The Coming Plague First published in 1994 in hardcover by Farrar, Straus and Giroux, THE COMING PLAGUE: Newly Emerging Diseases in a World Out of Balance was a New York Times bestseller in 1994-5. In April, thousands of rats stagger into the open and die. . But everything he had predicted in 1981 had, by 1991, transpired.”, “Campbell liked to remind fellow malariologists of the old British colonial scourge, blackwater fever. We have changed the whole face of the earth by the use of antibiotics.
And an immune species that thrived alongside Homo sapiens, such as vervet African green monkeys, might conceivably serve as an SIV / HIV conduit, carrying viruses back and forth between mixed monkey troops and humans. If you are at an office or shared network, you can ask the network administrator to run a scan across the network looking for misconfigured or infected devices. —Michiko Kakutani, The New York Times"This brilliant book conveys a grim message: that we may be entering a period of dramatic change in our relationship with infectious disease . After repeated episodes of malaria, each of which was treated with escalating doses of quinine, the nonimmune Europeans fell ill with what they thought was another infectious disease. Some viruses changed very slowly over time, probably because they possessed extremely accurate mechanisms for replication and repair of their genetic material. —Richard Horton, The New York Review of Books"Encyclopedic in detail, missionary in zeal, and disturbing in its message...The Coming Plague makes fascinating if troubling reading. The Coming Plague’s epic setting takes the reader from the rain forest of Amazonian South … Next, author Laurie Garrett discusses the outbreak of Bolivian Hemorrhagic Fever in Machupo, as mice were discovered to be the transmitters of the disease. No one could be certain how the immunodeficiency viruses zoonotically moved among primates in ancient Africa.”, “Consider the difference in size between some of the very tiniest and the very largest creatures on Earth. . Yet a bacterium can kill a whale…. Charlemagne’s conquest of Europe was slowed by an A.D. 876 flu epidemic that spread across the continent and claimed much of his army. With the Europeans came microbes to which the residents of the Americas had no natural immunity, and McNeill estimated, “Overall, the disaster to Amerindian populations assumed a scale that is hard for us to imagine. Yeasts secrete antibiotics to ward off attacking bacteria. —The New Yorker"The book is ambitious, but it succeeds...[its] scope is encyclopedic, its mass of detail startling." The Coming Plague makes fascinating if troubling reading. She was awarded the Pulitzer Prize for Explanatory Journalism in 1996 for a series of works published in Newsday, and has also been awarded the Polk and Peabody Prizes. Even though The Coming Plague was first published in 1994, it’s probably more relevant today than ever. They can actually live on a bar of soap. .
They are our predators and they will be victorious if we, Homo sapiens, do not learn how to live in a rational global village that affords the microbes few opportunities. Relying on extensive interviews with leading experts in virology, molecular biology, disease ecology, and medicine, as well as field research in sub-Saharan Africa, Western Europe, Central America, and the United States, Laurie Garrett's The Coming Plague takes readers from the savannas of eastern Bolivia to the rain forests of the northern Democratic Republic of the Congo on a harrowing, fifty year journey through the history of our battles …
Abundant sources of genetic variation exist for viruses to learn new tricks, not necessarily confined to what happens routinely, or even frequently.”, “As humans improve their lots, McNeill warned, they actually increase their vulnerability to disease. By the 1990s, when public health authorities and physicians were nervously watching their antimicrobial tools become obsolete, Lappé’s book was out of print. Many suspected influenza epidemics followed, though history can only vaguely discriminate between ancient accounts of influenza and other respiratory diseases. Never.”, “Eradication took eleven years, involving about a hundred highly trained professionals and thousands of local health workers and staff worldwide. They can survive in the detergent. Temporarily successful mosquito control programs eliminated the daily “vaccinations,” and immunity immediately disappeared. “The bottom lines: the units of natural selection — DNA, sometimes RNA elements — are by no means neatly packaged in discrete organisms. “But we’re not alone at the top of the food chain.” Our microbe predators are adapting, changing, evolving, he warned. —Michiko Kakutani, The New York Times"This brilliant book conveys a grim message: that we may be entering a period of dramatic change in our relationship with infectious disease . Sign up to receive information about new books, author events, and special offers. the possibility exists that a deadly and common organism could emerge that is easily spread from person to person and that might be aloof to all available therapeutic and preventive methods.”, “The microbe is nothing; the terrain everything.” — Louis Pasteur, “Over the long course of history, McNeill said, pathogenic microbes sought stability in their relationships with hosts. A large percentage of the humans would die of the disease during infancy, but survivors, who were “vaccinated” every day by mosquitoes that injected parasites into their blood, were immune, or, as Kent Campbell would put it, tolerant. Garrett has mastered an extraordinary amount of detail about the pathology, epidemiology, and human events surrounding dozens of complex diseases. During the plague such fear-driven repression led to the wholesale slaughter of Jews and of women accused of witchcraft.”, “That humanity had grossly underestimated the microbes was no longer, as the world approached the twenty-first century, a matter of doubt. —Richard A. Knox, The Boston Globe"Garrett has done a brilliant job of putting scientific work into layman's language, and the scariness of medical melodramas is offset by the excitement of scientific detection." “Are we better off today than we were a century ago? First, with the initial emergence of the microbe — plague bacteria or HIV — came denial in all tiers of society. Ratios of 20:1 or even 25:1 between pre-Columbian populations and the bottoming-out point in Amerindian population curves seem more or less correct.”, “Cities, in short, were microbe heavens, or, as British biochemist John Cairns put it, “graveyards of mankind.” The most devastating scourges of the past attained horrific proportions only when the microbes reached urban centers, where population density instantaneously magnified any minor contagion that might have originated in the provinces. I found it hard to put the book down." At times it does really feel like Laurie Garrett had a crystal ball for the coronavirus and pandemic, and that makes this book all the more incredible. They are the most tenacious organisms you can imagine. The level of detail is amazing, with fascinating portraits of the so-called 'disease cowboys,' the doctors and scientists who fight infectious diseases on the front lines.
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